DIGESTIVE
SUPPORT
IMMUNE SUPPORT
Nitric oxide plays many important roles in the immune system. It is produced in high amounts from specialized cells of the immune system called macrophages.
DIGESTIVE SUPPORT
In the gastrointestinal tract, Nitric Oxide is involved in the regulation of regional blood flow, smooth muscle relaxation, secretory and immunological function.[1]
VASCULAR SUPPORT
Since it was identified as the elusive endothelium-derived relaxing factor in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. [1]
MOBILITY SUPPORT
Nitric oxide (NO) can modulate the release of various inflammatory mediators from a wide range of cells participating in inflammatory responses (e.g., leukocytes, macrophages, mast cells, endothelial cells, and
platelets).[1]
MEMORY SUPPORT
Nitric oxide (NO) is well established as a molecule necessary for memory processing across a wide variety of tasks and species, from odour discrimination in honey bees (Muller, 1996) to delayed recall in primates (Prendergast et al., 1997). [1]
REST SUPPORT
Nitric Oxide helps reduce anxiety and depression in part because it reduces inflammation and oxidative stress. It also restores circulation and supports healthy blood pressure, which is often elevated in people under stress and with chronic PTSD, thus becoming another risk factor for vascular dementia. [1]
Digestive Support
In the gastrointestinal (GI) tract, nitric oxide (NO) has been shown over the last 25 years to exert a prominent function as inhibitory neurotransmitter. Apart from the regulation of secretion and resorption, NO from nitrergic neurons has been demonstrated to be crucial for GI smooth muscle relaxation and motility. [2]
Nitric oxide (NO) is known to have a protective effect on the gastrointestinal tract. In preclinical studies NO was shown to help maintain gastric mucosal integrity, to inhibit leukocyte adherence to the endothelium, and to repair NSAID-induced damage.[3]
Epidemiologic studies have shown that the use of NO-donating agents with NSAIDs or aspirin resulted in reduced risk for gastrointestinal bleeding. Recent studies have shown that cyclo-oxygenase inhibiting NO-donating drugs (CINODs), in which a NO molecule is chemically linked to an NSAID, are effective anti-inflammatory agents and may result in less gastrointestinal damage than is associated with NSAID use.[3]
References:
Digestive Support
[1] S. Moncada and E. A. Higgs, “Endogenous nitric oxide: physiology, pathology and clinical relevance,” European Journal of Clinical Investigation, vol. 21, no. 4, pp. 361–374, 1991.
[2] Integrative Control of Gastrointestinal Motility by Nitric Oxide. Groneberg D, Voussen B, Friebe A. Curr Med Chem. 2016;23(24):2715-2735. doi: 10.2174/0929867323666160812150907. PMID: 27528058 Review.
[3] Role of nitric oxide in the gastrointestinal tract. Lanas A. Arthritis Res Ther. 2008;10 Suppl 2(Suppl 2):S4. doi: 10.1186/ar2465. Epub 2008 Oct 17. PMID: 19007429 Free PMC article. Review. https://pubmed.ncbi.nlm.nih.gov/?term=Lanas+A&cauthor_id=19007429
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