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IMMUNE SUPPORT

Nitric oxide plays many important roles in the immune system. It is produced in high amounts from specialized cells of the immune system called macrophages.

DIGESTIVE SUPPORT

In the gastrointestinal tract, Nitric Oxide is involved in the regulation of regional blood flow, smooth muscle relaxation, secretory and immunological function. [1]

VASCULAR SUPPORT

Since it was identified as the elusive endothelium-derived relaxing factor in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. [1]

MOBILITY SUPPORT

Nitric oxide (NO) can modulate the release of various inflammatory mediators from a wide range of cells participating in inflammatory responses (e.g., leukocytes, macrophages, mast cells, endothelial cells, and
platelets).[1]

MEMORY SUPPORT

Nitric oxide (NO) is well established as a molecule necessary for memory processing across a wide variety of tasks and species, from odour discrimination in honey bees (Muller, 1996) to delayed recall in primates (Prendergast et al., 1997).[1]

REST SUPPORT

Nitric Oxide helps reduce anxiety and depression in part because it reduces inflammation and oxidative stress. It also restores circulation and supports healthy blood pressure, which is often elevated in people under stress and with chronic PTSD, thus becoming another risk factor for vascular dementia. [1]

Mobility Support

Nitric oxide (NO) plays an important role in mediating many aspects of inflammatory responses.[1] NO is an effector molecule of cellular injury, and can act as an anti-oxidant. It can modulate blood flow, adhesion of leukocytes to the vascular endothelium and the activity of numerous enzymes, all of which can have an impact on inflammatory responses.[1]
In recent years, NO-releasing drugs have been developed, usually as derivatives of other drugs, which exhibit very powerful anti-inflammatory effects.[1]

NO mediates many different cell functions at the site of synovial
inflammation, including cytokine production, signal transduction,
mitochondrial functions and apoptosis. The effects of NO depend on its concentration. Increased NO production plays an important role in the pathogenesis of both SLE and RA. Further studies are needed to determine the cellular and molecular mechanisms by which NO regulates immune cell functions. NOS inhibition may represent a novel therapeutic approach in the treatment of chronic autoimmune diseases.[2]

PDF Downloads:

  • Nitric Oxide-Scavenging Nanogel for Treating Rheumatoid Arthritis

References:

Mobility Support

[1] Nitric oxide as a regulator of inflammatory processes. John L Wallace. Mucosal Inflammation Research Group, Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada

[2] Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and sysemic lupus erythematosus. György Nagy, Agnes Koncz, Tiffany Telarico, David Fernandez, Barbara Érsek, Edit Buzás, András
Perl. Arthritis Res Ther. 2010; 12(3): 210. Published online 2010 Jun 28. doi: 10.1186/ar3045 PMCID: PMC2911902

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